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Hydrogels for therapeutic delivery: current developments and future directions

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Significant barriers still exist despite established safety profiles, such as high costs that restrict access worldwide, a lack of predictive biomarkers for treatment response, a lack of knowledge about the mechanistics of gut microbiota interactions, and an incomplete understanding of long-term safety, particularly with regard to thyroid and pancreatic effects

In vitro studies have also demonstrated that homocysteine inhibits the activity of dimethylarginine dimethylaminohydrolase (DDAH), the enzyme responsible for ADMA metabolism [21], [22]

Sumioka I, Matsura T, Yamada K